The Billroth Cord, Sinus of Red Pulp, and Erythrophagocytosis in Red Pulp

This article discusses the Billroth cord, sinus of red pulp, and erythrophagocytosis in red pulp. In addition, it describes the reticulum and sinusoids. These organs are permeated by fine fibrous reticular meshwork. In addition, the sinusoids contain ring-like formations of reticular fibers.

Billroth cords

The Billroth cords and sinus of red plum are open blood vessels composed of lymphatic tissue and reticular cells. Each line contains varying numbers of red blood corpuscles and lymphocytes. In the fresh, unfixed state, the cords’ red color is attributed to the presence of phagocytic reticular cells.

The Billroth cords comprise a three-dimensional network of fibroblastic reticular cells between branched sinuses. The plexus contains many large, open spaces, about 300 microns in the area and 30 to 100 microns thick. These cavities bypass the narrow-gauge filtration beds of the spleen.

Central arterioles connect the Billroth cords and sinus of red and white pulps. Their vascular channels are easily distinguished. The vascular sinus also shows unusual lining cells. It is possible to identify the Billroth cords and sinus of red pulp by studying a histological slide.

Unlike other reticuloendothelial organs, the spleen has a more complex structure. Its afferent arterioles exit from lymphoid nodules and terminate in the Billroth cords. Here, blood cells are discharged. In this process, they are greeted by macrophages and come in direct contact with several classes of lymphocytes.

The Billroth Cord, Sinus of Red Pulp, and Erythrophagocytosis in Red Pulp photo 3

The red pulp is the primary source of red blood cells. It is a mechanical meshwork that removes damaged, senescent and abnormal erythrocytes. Those cells can no longer pass through the narrow spaces between the spleen sinusoids. The removed cells are broken down by phagocytes living in the red pulp.


The sinusoids of red pulp contain a complex array of macrophages. These immune cells are located in the marginal sinus and are attached to the reticular walls of the red pulp vascular spaces. These cells are derived from bone marrow, circulating as monocytes and migrating to the spleen. Some of these cells are replenished by local proliferation, while others migrate into the adjacent red pulp.

The sinusoids are vascularized structures containing blood cells, lymphocytes, and macrophages. They perform a variety of immunological functions. These structures are connected to the blood through peripheral arteries. To study sinusoids, the PAS technique is used. This technique highlights the network of reticular fibers within the sinusoids. The reticular tissue contains numerous macrophages, lymphocytes, polymorphs, platelets, and other cells. It also includes groups of plasma cells located along the trabeculae and marginal zones. A thick capsule covering the sinusoids is made up of reticular tissue.

The sinusoids of red pulp contain several vascular tributaries that drain into the splenic vein. These blood spaces are home to the splenic cords of Billroth and blood cells. The normal spleen weighs approximately 150 grams and contains a variety of venous sinuses.

There are also spherical masses attached to the visceral surface of the spleen. These are often found in old dogs, as well as in swine. Moreover, they are associated with septicemic diseases. These lesions may be difficult to distinguish, as no definitive diagnosis exists.

The Billroth Cord, Sinus of Red Pulp, and Erythrophagocytosis in Red Pulp photo 2

Sinusoids of red pulp are surrounded by reticular connective tissue and macrophages. These cells are responsible for filtering blood and destroying old blood cells. The red pulp also contains lymphoid follicles, which consist of B and T lymphocytes. The cells of red pulp are vital for recycling iron and red blood cell turnover. The red pulp’s unique structure enables this process to occur.

While nonsinusoidal spleens lack perisinusoidal macrophages, they have the same function. They facilitate leukocyte migration from the Cords of Billroth into the bloodstream. Various antibodies to the intermediate filament protein vimentin and T-cell antigen Leu 2 have been used to visualize sinusoids and confirm their existence.


The reticular cord and sinus of red pulp comprise two distinct cellular structures, the Billroth cord, and the sinus. Both cellular installations are permeated by fine fibrous reticular meshwork. The Billroth cords are separated from the sinusoids by a ring-like structure.

The reticular cord and sinus of red pulp are supported by stromal cells and lined with endothelial cells. These endothelial cells contain slits between them, which red blood cells use to migrate. The cord and sinus are also home to plasma cells, macrophages, and lymphocytes.

Capillaries in the red pulp and sinus of red pulp are not uniformly distributed. They tend to be denser in the perifollicular capillary net, which lies inside the follicle. This network receives the major bloodborne antigen and oxygen supplies.

The Billroth Cord, Sinus of Red Pulp, and Erythrophagocytosis in Red Pulp photo 1

The reticular cord and sinus of red pulp contain numerous phagocytes. These cells also play a significant role in the immune system. These cells are particularly abundant in the red pulp and function as mechanical meshwork to remove damaged, senescent, and abnormal erythrocytes.

The spleen consists of two main types of pulp: white and red. The white pulp is a lymphoid tissue that responds to bloodborne antigens. Both pulps are enclosed in a capsule that contains dense connective tissue. The tablets of both types of pulp contain a large number of conspicuous trabeculae. These trabecular branches branch out to the splenic vein.

Erythrophagocytosis in the red pulp

Erythrophagocytosis in the cord and sinus of red pulp is a condition in which red blood cells are taken up by macrophages and transported to a phagocytic cell. This type of blood phagocytosis is essential for recycling iron and turning red blood cells. This process is possible in the cord and sinus of red pulp because of the unique structure of these tissues.

Red pulp macrophages are highly diverse and reside in the red pulp and spleen. They are essential for blood homeostasis and are responsible for the phagocytosis of injured and senescent erythrocytes. Macrophages are also involved in the phagocytosis of bloodborne particles. Red pulp macrophages are maintained throughout life and are a source of defense against infections and infectious diseases. The red pulp is rich in macrophages, which can rapidly multiply during inflammation.

HS in the red pulp involves various organs in the body, including the spleen, liver, bone marrow, and lung. Histiocytes invade the red pulp in the spleen and enter the sinuses and cord of the red pulp. Histiocytes in the red pulp were associated with fibrin deposition and focal areas of fibrin deposition.

The Billroth Cord, Sinus of Red Pulp, and Erythrophagocytosis in Red Pulp photo 0

Erythrophagocytosis in the cord and sinus of red pulp is associated with reduced oxygen consumption levels. The cell walls are lined with aligned endothelial cells and connect with annular fibers. These cell walls were studied with TEM and computational modeling to understand the path of RBCs through the IES. The slits in the sinuses have an average height of 0.65 mm and range in length from 0.9 to 3.2 mm.

The red pulp is the most significant portion of the spleen, but it lacks the well-defined organization of the white pulp. It is made up of a meshwork of cords and sinuses. They form an open blood system in the spleen and are connected to the central artery (MZ). The spleen also contains numerous venous sinuses scattered throughout the red pulp, serving as exit sites for circulating cells and blood.

Erythropoiesis is an essential process in mammals. It produces 2.5 million red blood cells per second and recycles enormous amounts of iron. A large part of the iron is recycled from aged erythrocytes. RPMs play a crucial role in this process.

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